BTN3A3 and CTSL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BTN3A3	CTSL
Description		butyrophilin subfamily 3 member A3	cathepsin L
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Body	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Signaling Receptor Binding Protein Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Immune System Process T Cell Mediated Immunity T Cell Receptor Signaling Pathway	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Butyrophilin (BTN) family interactions	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs			L-cysteic acid Felbinac Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30578418) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 34187846) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: ACE2 ARL8B CTSL	29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		10384	1514
HPRD ID		12548	00293
Ensembl ID		ENSG00000111801	ENSG00000135047
Uniprot IDs		O00478	P07711 Q5T8F0 Q9HBQ7
PDB IDs		4F8T 5ZZ3 6J0G 6J0K 6J0L	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC
Enriched GO Terms of Interacting Partners?		Biological Process Involved In Interaction With Host Viral Process Membrane Fusion Receptor-mediated Endocytosis Of Virus By Host Cell Endocytosis Involved In Viral Entry Into Host Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Membrane Organization Antigen Processing And Presentation Serpin Family Protein Binding Symbiont Entry Into Host Cell Fusion Of Virus Membrane With Host Endosome Membrane Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Viral Exocytosis Vesicle-mediated Transport Receptor-mediated Endocytosis Protein Processing Enkephalin Processing Endosome To Lysosome Transport Of Low-density Lipoprotein Particle Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Hormone Metabolic Process Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Calcium Ion Regulated Lysosome Exocytosis Protein Localization To Early Endosome Entry Receptor-mediated Virion Attachment To Host Cell Chromaffin Granule Cytolytic Granule Membrane Viral Translation Viral Life Cycle Hydrolase Activity Elastin Metabolic Process Endolysosome Lumen Tryptophan Transport Protein Maturation Inflammatory Cell Apoptotic Process Positive Regulation Of Gap Junction Assembly Receptor-mediated Virion Attachment To Host Cell Apical Plasma Membrane Vesicle-mediated Cholesterol Transport Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gap Junction Assembly Extracellular Exosome Aromatic Amino Acid Transport Drinking Behavior	Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process
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