SMYD5 and NAT8

		SMYD5	NAT8
Description		SMYD family member 5	N-acetyltransferase 8 (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4K20 Trimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups L-cysteine-S-conjugate N-acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	Cytoplasmic Translation Methylation Negative Regulation Of Gene Expression, Epigenetic Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Cytoplasmic Translational Elongation Regulation Of Stem Cell Division Regulation Of Stem Cell Differentiation	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Amyloid Fibril Formation
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Macrovascular complications in type 2 diabetes ( 33430853) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)
Interacting Genes		6 interacting genes: H1-1 H2BC3 H3C1 H4C1 ZNF417 ZNF587	31 interacting genes: AQP6 ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MTIF3 REEP2 SAR1A SLC10A6 SLC71A2 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TRIM21 TSPAN31 YIPF4
Entrez ID		10322	9027
HPRD ID		18080	08413
Ensembl ID		ENSG00000135632	ENSG00000144035
Uniprot IDs		Q6GMV2	Q9UHE5
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly DNA Binding Chromatin Remodeling Chromosome Chromatin Organization Protein Heterodimerization Activity Chromosome Organization L-cysteine-S-conjugate N-acetyltransferase Activity Protein-containing Complex Assembly Peptidyl-lysine N6-acetylation Telomere Organization Protein-containing Complex Organization Chromosome, Telomeric Region L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation N-acetyltransferase Activity CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation	Membrane Endoplasmic Reticulum
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