UGCG

Description		UDP-glucose ceramide glucosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding Ceramide Glucosyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Protein Lipidation Lipid Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Biosynthetic Process Glycosphingolipid Biosynthetic Process Epidermis Development Regulation Of Signal Transduction Cell Differentiation Keratinocyte Differentiation Leptin-mediated Signaling Pathway Neuron Development Establishment Of Skin Barrier Intestinal Lipid Absorption Cornified Envelope Assembly
Pathways		Glycosphingolipid biosynthesis
Drugs		Miglustat Eliglustat
Diseases
GWAS		Benign prostatic hyperplasia ( 30988330) Mean corpuscular hemoglobin ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		3 interacting genes: APP RTN1 RTN3
Entrez ID		7357
HPRD ID		04190
Ensembl ID		ENSG00000148154
Uniprot IDs		Q16739
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Amyloid Precursor Protein Catabolic Process Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Neuron Projection Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Organization Regulation Of Amide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Apparatus Brain Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Postsynaptic Density Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Neuron Differentiation Heparan Sulfate Binding
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