OLIG2 and LRRFIP1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		OLIG2	LRRFIP1
Description		oligodendrocyte transcription factor 2	LRR binding FLII interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Nervous System Development Sensory Organ Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Oligodendrocyte Cell Fate Specification Thalamus Development Central Nervous System Neuron Differentiation Neuron Differentiation Myelination Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Axon Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Signaling by cytosolic FGFR1 fusion mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 in disease
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Caffeine consumption from tea ( 33287642) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 31527586) Tea consumption ( 31046077)	Adiposity ( 23505185) Apolipoprotein A1 levels ( 32203549) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 30294719)
Interacting Genes		16 interacting genes: CKAP5 CUL3 EP300 EXOC7 GOLGA3 HEY1 KRTAP12-4 LRRFIP1 MCF2L2 MRFAP1L1 NAP1L2 NKX2-2 PSMA3 SOX10 SOX8 TXLNA	9 interacting genes: CEP44 FBXO7 FLII MED4 OLIG2 RNF10 SERPINB5 SH2D2A TSG101
Entrez ID		10215	9208
HPRD ID		07334	04460
Ensembl ID		ENSG00000205927	ENSG00000124831
Uniprot IDs		Q13516	A0A0F7NGI8 B4DPC0 Q32MZ4
PDB IDs			4H22
Enriched GO Terms of Interacting Partners?		Oligodendrocyte Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Gliogenesis Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Neuron Differentiation Enteric Nervous System Development Regulation Of Gliogenesis Glial Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Chromatin Oligodendrocyte Development Regulation Of Neurogenesis Peripheral Nervous System Development Regulation Of Cell Development Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Propionylation Swimming Cell Fate Commitment Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Negative Regulation Of DNA-templated Transcription Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Development Histone Crotonyltransferase Activity DNA-binding Transcription Factor Binding Regulation Of Cell Division Response To Progesterone Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Regulation Of Nervous System Development Transcription Elongation By RNA Polymerase II Positive Regulation Of Cytokinesis Microtubule Plus End Polymerase Histone H2B Acetyltransferase Activity Animal Organ Development Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Destabilization Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of TORC1 Signaling Histone Acetyltransferase Regulator Activity Pancreatic A Cell Fate Commitment
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