OLIG2 and SOX10

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (in vitro)

		OLIG2	SOX10
Gene Name		oligodendrocyte lineage transcription factor 2	SRY (sex determining region Y)-box 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Extrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity HMG Box Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Thalamus Development Myelination Negative Regulation Of Neuron Differentiation Neuron Fate Commitment Positive Regulation Of Oligodendrocyte Differentiation	In Utero Embryonic Development Neural Crest Cell Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gliogenesis Melanocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457)
Protein-Protein Interactions		5 interactors: CUL3 EP300 NKX2-2 SOX10 SOX8	28 interactors: ALX4 CDK6 CEBPA DLX5 EGR2 EXOC5 HHEX HIVEP1 HOXA3 HOXC4 JUN MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1
Entrez ID		10215	6663
HPRD ID		07334	03752
Ensembl ID		ENSG00000205927	ENSG00000100146
Uniprot IDs		Q13516	B4DV62 P56693
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gliogenesis Oligodendrocyte Differentiation Regulation Of Gliogenesis Enteric Nervous System Development Tube Development Glial Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Glial Cell Fate Commitment Gliogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Embryo Development Astrocyte Differentiation Autonomic Nervous System Development Neural Crest Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Positive Regulation Of Metabolic Process Neural Crest Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Development In Utero Embryonic Development Positive Regulation Of Cellular Biosynthetic Process Neural Crest Cell Differentiation Epithelial Cell Differentiation Tissue Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Peripheral Nervous System Development Histone H2B Acetylation Type B Pancreatic Cell Fate Commitment Ventral Spinal Cord Interneuron Fate Determination Mesenchymal Cell Development Regulation Of Neurogenesis Negative Regulation Of Cellular Metabolic Process Mesenchymal Cell Differentiation Digestive Tract Development Skeletal Muscle Tissue Development Multicellular Organismal Development Cell Maturation Negative Regulation Of Canonical Wnt Signaling Pathway Skeletal Muscle Organ Development Digestive System Development Anatomical Structure Development Positive Regulation Of Cell Proliferation Pancreatic A Cell Fate Commitment Retinal Rod Cell Differentiation	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Tissue Development Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process System Development Macromolecule Biosynthetic Process Protein Sumoylation Embryonic Morphogenesis Anatomical Structure Development Embryonic Organ Development Embryo Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Cellular Nitrogen Compound Metabolic Process Pattern Specification Process Embryonic Organ Morphogenesis Organ Morphogenesis Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Cell Proliferation Gland Development
Tagcloud ?		briona choices cns competent cure dbx decisive dorsky expresses fate glia hidden homeobox implication lacks larvae mammals manipulations massive microenvironment neurogenic notion placed pronounced radial reactivate regeneration vertebrate zebrafish	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally specification stationary temporally unexpected
Tagcloud (Difference) ?		briona choices cns competent cure dbx decisive dorsky expresses fate glia hidden homeobox implication lacks larvae mammals manipulations massive microenvironment neurogenic notion placed pronounced radial reactivate regeneration vertebrate zebrafish	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally specification stationary temporally unexpected
Tagcloud (Intersection) ?