OLIG2 and NKX2-2

Number of citations of the paper that reports this interaction (PMID 14573534)
14

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		OLIG2	NKX2-2
Gene Name		oligodendrocyte lineage transcription factor 2	NK2 homeobox 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm
	Molecular Function	DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity HMG Box Domain Binding	Core Promoter Proximal Region DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Thalamus Development Myelination Negative Regulation Of Neuron Differentiation Neuron Fate Commitment Positive Regulation Of Oligodendrocyte Differentiation	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Transcription, DNA-templated Smoothened Signaling Pathway Brain Development Response To Glucose Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ventral Spinal Cord Interneuron Fate Determination
Pathways			Regulation of beta-cell development Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457)
Protein-Protein Interactions		5 interactors: CUL3 EP300 NKX2-2 SOX10 SOX8	1 interactors: OLIG2
Entrez ID		10215	4821
HPRD ID		07334	05213
Ensembl ID		ENSG00000205927	ENSG00000125820
Uniprot IDs		Q13516	O95096
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gliogenesis Oligodendrocyte Differentiation Regulation Of Gliogenesis Enteric Nervous System Development Tube Development Glial Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Glial Cell Fate Commitment Gliogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Embryo Development Astrocyte Differentiation Autonomic Nervous System Development Neural Crest Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Positive Regulation Of Metabolic Process Neural Crest Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Development In Utero Embryonic Development Positive Regulation Of Cellular Biosynthetic Process Neural Crest Cell Differentiation Epithelial Cell Differentiation Tissue Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Peripheral Nervous System Development Histone H2B Acetylation Type B Pancreatic Cell Fate Commitment Ventral Spinal Cord Interneuron Fate Determination Mesenchymal Cell Development Regulation Of Neurogenesis Negative Regulation Of Cellular Metabolic Process Mesenchymal Cell Differentiation Digestive Tract Development Skeletal Muscle Tissue Development Multicellular Organismal Development Cell Maturation Negative Regulation Of Canonical Wnt Signaling Pathway Skeletal Muscle Organ Development Digestive System Development Anatomical Structure Development Positive Regulation Of Cell Proliferation Pancreatic A Cell Fate Commitment Retinal Rod Cell Differentiation	Spinal Cord Oligodendrocyte Cell Fate Specification Oligodendrocyte Cell Fate Specification Thalamus Development Positive Regulation Of Oligodendrocyte Differentiation Glial Cell Fate Commitment Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Spinal Cord Motor Neuron Differentiation Positive Regulation Of Gliogenesis Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Regulation Of Glial Cell Differentiation Oligodendrocyte Differentiation Neuron Fate Commitment Diencephalon Development Cell Fate Specification Regulation Of Gliogenesis Spinal Cord Development Myelination Axon Ensheathment Glial Cell Differentiation Negative Regulation Of Neuron Differentiation Central Nervous System Neuron Differentiation Gliogenesis Negative Regulation Of Neurogenesis Cell Fate Commitment
Tagcloud ?		briona choices cns competent cure dbx decisive dorsky expresses fate glia hidden homeobox implication lacks larvae mammals manipulations massive microenvironment neurogenic notion placed pronounced radial reactivate regeneration vertebrate zebrafish
Tagcloud (Difference) ?		briona choices cns competent cure dbx decisive dorsky expresses fate glia hidden homeobox implication lacks larvae mammals manipulations massive microenvironment neurogenic notion placed pronounced radial reactivate regeneration vertebrate zebrafish
Tagcloud (Intersection) ?