PDZK1IP1 and THBD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDZK1IP1	THBD
Description		PDZK1 interacting protein 1	thrombomodulin
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Extracellular Space Vacuolar Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apicolateral Plasma Membrane Serine-type Endopeptidase Complex
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity
	Biological Process		Proteolysis Female Pregnancy Blood Coagulation Hemostasis Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Zymogen Activation Response To Lipopolysaccharide Negative Regulation Of Coagulation Response To CAMP Negative Regulation Of Fibrinolysis Blood Coagulation, Common Pathway
Pathways			Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall
Drugs			Drotrecogin alfa Ibuprofen Dexibuprofen
Diseases			Inherited thrombophilia
GWAS		Clozapine-induced agranulocytosis ( 25187353)	Blood protein levels in cardiovascular risk ( 28369058) Lung function (FVC) in asthma ( 32989782) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)
Interacting Genes		77 interacting genes: AGR3 AIG1 APOA2 APOD AQP2 AQP6 ARL13B ASGR1 C14orf180 C2CD2L CD81 CES1 CLDN19 COPS6 CYB5B CYBC1 EMC6 ERG28 FAM3C FCER1G GALNT15 GAST GIMAP5 GRM2 GYPA HMOX1 ICMT IGFBP5 JAGN1 LEPROTL1 LHFPL5 MIP MYADM MYADML2 NSG1 NUMB PDZK1 PEX16 PGAP2 PLP2 PLPP4 PLPP6 PMP22 RPRM RTP2 SDCBP SFTPC SFXN2 SLC22A1 SLC22A2 SLC35B1 SLC35B4 STRIT1 STX12 THBD TMEM101 TMEM107 TMEM109 TMEM11 TMEM140 TMEM14A TMEM14B TMEM14C TMEM203 TMEM39B TMEM65 TMEM86A TMEM97 TNFRSF10C TRARG1 TRIM54 TSPO2 UPK1B UTP14A VAMP3 YIPF6 ZDHHC17	33 interacting genes: AIG1 APOC2 APOC4 AQP6 CD79A CIDEB CYBC1 EBP ERGIC3 F2 FAM209A FCER1G GPR152 GPX8 KIR2DL3 LMNA MMGT1 MTIF3 MUC1 PDZK1IP1 PF4 PHF24 PROC PSENEN RHBDD2 SERPINA5 SLC10A6 SLC19A3 SLC35H1 TMEM14B TMEM35A TMEM86B TMX2
Entrez ID		10158	7056
HPRD ID		06211	01764
Ensembl ID		ENSG00000162366	ENSG00000178726
Uniprot IDs		Q13113	P07204
PDB IDs		7VSI 7WMV 7YNI 7YNJ 7YNK 8HB0 8HDH 8HEZ 8HG7 8HIN	1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3 7T4R
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Localization Within Membrane Organic Hydroxy Compound Transport Protein Binding Cholesterol Binding Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Cellular Response To Lipoprotein Particle Stimulus Quaternary Ammonium Group Transport Water Channel Activity Cellular Localization Organic Cation Transport Putrescine Transmembrane Transporter Activity Lipid Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Transmembrane Transport Water Transport Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Protein Localization To Plasma Membrane Cholesterol Transport Monoamine Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Cellular Response To Low-density Lipoprotein Particle Stimulus Carnitine Transmembrane Transport Carnitine Transport Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Sterol Transport Regulation Of Transport Renal Water Transport Fluid Transport Heme Metabolic Process Serotonin Uptake Norepinephrine Transport Neutrophil Differentiation	Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Lipid Transport Protein Binding Organic Hydroxy Compound Transport Identical Protein Binding Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Positive Regulation Of Protein Localization To Cell Surface Very-low-density Lipoprotein Particle
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