ACOT8 and P4HA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACOT8	P4HA3
Description		acyl-CoA thioesterase 8	prolyl 4-hydroxylase subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Acetyl-CoA Hydrolase Activity Succinyl-CoA Hydrolase Activity Protein Binding Acyl-CoA Hydrolase Activity Hydrolase Activity Choloyl-CoA Hydrolase Activity Acetoacetyl-CoA Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Hydroxymethylglutaryl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Medium-chain Fatty Acyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Peroxisome Organization Fatty Acid Catabolic Process Negative Regulation Of Glycoprotein Biosynthetic Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Dicarboxylic Acid Catabolic Process Fatty Acid Derivative Biosynthetic Process	Collagen Fibril Organization
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import	Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS			Hippocampal atrophy ( 25625606)
Interacting Genes		6 interacting genes: CFTR FBXO7 P4HA3 PEX5 PRDM16 REL	49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A
Entrez ID		10005	283208
HPRD ID		06998	16413
Ensembl ID		ENSG00000101473	ENSG00000149380
Uniprot IDs		A0A494C0N6 E9PJN0 O14734	Q7Z4N8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Multicellular Organism Growth Regulation Of Cellular Respiration Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Cell Communication Positive Regulation Of Anion Channel Activity Regulation Of Signaling Positive Regulation Of Monoatomic Anion Transport Directional Locomotion Neuromuscular Process Response To Butyrate Cellular Response To Hydrostatic Pressure Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Lewy Body Core Negative Regulation Of Hemopoiesis Positive Regulation Of Enamel Mineralization Phosphatidylinositol 3-kinase Complex, Class IB Regulation Of Generation Of Precursor Metabolites And Energy Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking NF-kappaB Complex Positive Regulation Of Tooth Mineralization Transepithelial Water Transport Regulation Of Developmental Process Autosome Genomic Imprinting Negative Regulation Of Neuron Apoptotic Process Response To Hydrostatic Pressure Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Histone H3K9 Monomethyltransferase Activity Procollagen-proline 4-dioxygenase Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization NMDA Glutamate Receptor Activity Sleep 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation	Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding
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