ACOT8

Description		acyl-CoA thioesterase 8
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Acetyl-CoA Hydrolase Activity Succinyl-CoA Hydrolase Activity Protein Binding Acyl-CoA Hydrolase Activity Hydrolase Activity Choloyl-CoA Hydrolase Activity Acetoacetyl-CoA Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Hydroxymethylglutaryl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Medium-chain Fatty Acyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Peroxisome Organization Fatty Acid Catabolic Process Negative Regulation Of Glycoprotein Biosynthetic Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Dicarboxylic Acid Catabolic Process Fatty Acid Derivative Biosynthetic Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS
Novel Interacting Genes		2 novel interacting genes: GRIN2A PIK3CA
Interacting Genes		6 interacting genes: CFTR FBXO7 P4HA3 PEX5 PRDM16 REL
Entrez ID		10005
HPRD ID		06998
Ensembl ID		ENSG00000101473
Uniprot IDs		A0A494C0N6 E9PJN0 O14734
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Multicellular Organism Growth Regulation Of Cellular Respiration Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Cell Communication Positive Regulation Of Anion Channel Activity Regulation Of Signaling Positive Regulation Of Monoatomic Anion Transport Directional Locomotion Neuromuscular Process Response To Butyrate Cellular Response To Hydrostatic Pressure Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Lewy Body Core Negative Regulation Of Hemopoiesis Positive Regulation Of Enamel Mineralization Phosphatidylinositol 3-kinase Complex, Class IB Regulation Of Generation Of Precursor Metabolites And Energy Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking NF-kappaB Complex Positive Regulation Of Tooth Mineralization Transepithelial Water Transport Regulation Of Developmental Process Autosome Genomic Imprinting Negative Regulation Of Neuron Apoptotic Process Response To Hydrostatic Pressure Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Histone H3K9 Monomethyltransferase Activity Procollagen-proline 4-dioxygenase Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization NMDA Glutamate Receptor Activity Sleep 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation
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