PPFIA1 and SHANK2

		PPFIA1	SHANK2
Description		PPFI scaffold protein A1	SH3 and multiple ankyrin repeat domains 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Cell Cortex Axon Dendrite Protein-containing Complex Presynaptic Active Zone Spine Apparatus Schaffer Collateral - CA1 Synapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Cortical Microtubule Organization Synapse Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Protein Localization To Plasma Membrane	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte count ( 32888494)	Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		33 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 CNKSR1 DRC4 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS SHANK2 TNNT1 TXLNA USP7 YWHAG	34 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		8500	22941
HPRD ID		11451	04479
Ensembl ID		ENSG00000131626	ENSG00000162105
Uniprot IDs		A0AAG2UWZ2 B3KVS8 Q13136	A0A590UJ45 A6NHU9 Q9UPX8
PDB IDs		1N7F	8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Synapse Organization Presynaptic Active Zone Cell Junction Organization Maintenance Of Synapse Structure Presynaptic Active Zone Organization Presynaptic Active Zone Cytoplasmic Component Cell Junction Maintenance Transmembrane Receptor Protein Tyrosine Phosphatase Activity Synapse Presynaptic Membrane Cellular Component Maintenance Synaptic Membrane Adhesion Gamma-tubulin Binding Protein Tyrosine Phosphatase Activity Modulation Of Chemical Synaptic Transmission Cell Projection Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Presynapse Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Postsynaptic Density Cytosol Phosphoprotein Phosphatase Activity Regulation Of Dendritic Spine Development Growth Cone Maintenance Of Postsynaptic Specialization Structure Cytoplasm Centrosome Inhibitory Synapse Protein Phosphatase Type 2A Complex Regulation Of Postsynaptic Density Assembly Protein Phosphatase Activator Activity Heparan Sulfate Proteoglycan Binding Protein Dephosphorylation Presynapse Organization Glutamatergic Synapse Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Postsynaptic Specialization Organization Regulation Of Axon Regeneration Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Neuron Projection Regeneration Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Plasma Membrane Raft Distribution Chondroitin Sulfate Proteoglycan Binding Slow-twitch Skeletal Muscle Fiber Contraction Structural Constituent Of Presynapse	Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse
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