PPFIA1 and PPP2R5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPFIA1	PPP2R5A
Description		PPFI scaffold protein A1	protein phosphatase 2 regulatory subunit B'alpha
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GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Cell Cortex Axon Dendrite Protein-containing Complex Presynaptic Active Zone Spine Apparatus Schaffer Collateral - CA1 Synapse	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Z Disc M Band
	Molecular Function	Protein Binding	Protein Binding Kinase Inhibitor Activity Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Cell-matrix Adhesion Signal Transduction Cortical Microtubule Organization Synapse Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Protein Localization To Plasma Membrane	Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte count ( 32888494)	Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 CNKSR1 DRC4 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS SHANK2 TNNT1 TXLNA USP7 YWHAG	29 interacting genes: APC AXIN2 BCL2 BEST1 BUB1B CDCA2 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NEK2 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1
Entrez ID		8500	5525
HPRD ID		11451	03384
Ensembl ID		ENSG00000131626	ENSG00000066027
Uniprot IDs		A0AAG2UWZ2 B3KVS8 Q13136	Q15172
PDB IDs		1N7F	6NTS 8SZK
Enriched GO Terms of Interacting Partners?		Synapse Organization Presynaptic Active Zone Cell Junction Organization Maintenance Of Synapse Structure Presynaptic Active Zone Organization Presynaptic Active Zone Cytoplasmic Component Cell Junction Maintenance Transmembrane Receptor Protein Tyrosine Phosphatase Activity Synapse Presynaptic Membrane Cellular Component Maintenance Synaptic Membrane Adhesion Gamma-tubulin Binding Protein Tyrosine Phosphatase Activity Modulation Of Chemical Synaptic Transmission Cell Projection Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Presynapse Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Postsynaptic Density Cytosol Phosphoprotein Phosphatase Activity Regulation Of Dendritic Spine Development Growth Cone Maintenance Of Postsynaptic Specialization Structure Cytoplasm Centrosome Inhibitory Synapse Protein Phosphatase Type 2A Complex Regulation Of Postsynaptic Density Assembly Protein Phosphatase Activator Activity Heparan Sulfate Proteoglycan Binding Protein Dephosphorylation Presynapse Organization Glutamatergic Synapse Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Postsynaptic Specialization Organization Regulation Of Axon Regeneration Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Neuron Projection Regeneration Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Plasma Membrane Raft Distribution Chondroitin Sulfate Proteoglycan Binding Slow-twitch Skeletal Muscle Fiber Contraction Structural Constituent Of Presynapse	Cell Division Organelle Organization Protein Serine Kinase Activity Protein Kinase Activity Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Protein Serine/threonine Kinase Activity Kinase Activity Beta-catenin Destruction Complex Negative Regulation Of Osteoblast Proliferation Protein Phosphorylation Regulation Of Organelle Organization Protein Autophosphorylation Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Phosphorylation Chromosome Segregation Regulation Of Nuclear Division Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Cytosol Kinetochore Chromosome, Centromeric Region Centrosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Osteoblast Proliferation Regulation Of Protein Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Cytoskeleton Organization Negative Regulation Of Cell Cycle Phase Transition Protein Phosphatase Regulator Activity Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Cell Cycle Phase Transition Cytoskeleton Microtubule Cytoskeleton Organization Nuclear Chromosome Segregation Chromosome Signal Transduction Nucleus Axon Development Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Regulation Of Signaling
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