SHANK2 and MCF2

		SHANK2	MCF2
Description		SH3 and multiple ankyrin repeat domains 2	MCF.2 cell line derived transforming sequence
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Dendrite Development Intracellular Signal Transduction Negative Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Leukemia Inhibitory Factor
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Metabolite levels ( 23823483)
Interacting Genes		34 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	9 interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG SHANK2 STUB1 TNK2
Entrez ID		22941	4168
HPRD ID		04479	02406
Ensembl ID		ENSG00000162105	ENSG00000101977
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	B2R9S6 P10911
PDB IDs		8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse	Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette GTPase Activity Regulation Of Postsynapse Assembly Intracellular Signal Transduction Postsynapse Rho Protein Signal Transduction G Protein Activity Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Regulation Of Vascular Associated Smooth Muscle Contraction Secretory Granule Membrane GTP Binding Positive Regulation Of Protein Modification Process Focal Adhesion Regulation Of Cell Shape Regulation Of Postsynapse Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Binding Regulation Of Synapse Assembly Rac Protein Signal Transduction Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein-containing Complex Assembly Heterotrimeric G-protein Complex Telencephalon Cell Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Protein Modification Process Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Membrane Invagination Cortical Cytoskeleton Organization Regulation Of Cell Morphogenesis Regulation Of Fibroblast Migration Actin Filament Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Brush Border Membrane Ficolin-1-rich Granule Membrane Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Metabolic Process Regulation Of Focal Adhesion Assembly Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
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