SHANK2 and RIPOR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHANK2	RIPOR3
Description		SH3 and multiple ankyrin repeat domains 2	RIPOR family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Protein Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		34 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	5 interacting genes: CCDC125 RHOC SCML4 SHANK2 TRAF1
Entrez ID		22941	140876
HPRD ID		04479	12757
Ensembl ID		ENSG00000162105	ENSG00000042062
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	A0A499FJE4 B7Z3F0 B7Z5S0 Q96MK2
PDB IDs		8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse	Positive Regulation Of Hydrolase Activity Skeletal Muscle Satellite Cell Migration Regulation Of Intracellular Signal Transduction Synaptic Receptor Adaptor Activity Apical Junction Assembly Cell Junction Assembly Positive Regulation Of Lipase Activity Positive Regulation Of Catalytic Activity Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding Neurofilament
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