SHANK2 and ANO1

		SHANK2	ANO1
Description		SH3 and multiple ankyrin repeat domains 2	anoctamin 1
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane	Nucleoplasm Plasma Membrane Membrane Apical Plasma Membrane Chloride Channel Complex Cell Projection Synapse Extracellular Exosome Presynapse
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Signaling Receptor Binding Calcium-activated Cation Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Iodide Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Dimerization Activity
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Monoatomic Ion Transport Chloride Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Iodide Transport Monoatomic Ion Transmembrane Transport Cellular Response To Heat Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Mucus Secretion Protein Localization To Membrane Monoatomic Cation Transmembrane Transport Glial Cell Projection Elongation Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Stimuli-sensing channels Induction of Cell-Cell Fusion
Drugs			Crofelemer
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Basophil count ( 32888494) Birth weight ( 31043758) Childhood ear infection ( 27182965 28928442) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Haemorrhoidal disease ( 33888516) Monobrow ( 27182965) Survival in rectal cancer ( 25866641) Systolic blood pressure ( 30578418) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		34 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	3 interacting genes: COPB1 SHANK2 TRIM23
Entrez ID		22941	55107
HPRD ID		04479	18202
Ensembl ID		ENSG00000162105	ENSG00000131620
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	Q5XXA6 Q9NW72
PDB IDs		8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse
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