PPFIA1 and PPP2R5D

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		PPFIA1	PPP2R5D
Description		PPFI scaffold protein A1	protein phosphatase 2 regulatory subunit B'delta
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GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Cell Cortex Axon Dendrite Protein-containing Complex Presynaptic Active Zone Spine Apparatus Schaffer Collateral - CA1 Synapse	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Cell-matrix Adhesion Signal Transduction Cortical Microtubule Organization Synapse Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Protein Localization To Plasma Membrane	Signal Transduction Nervous System Development Meiotic Sister Chromatid Cohesion
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte count ( 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		33 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 CNKSR1 DRC4 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS SHANK2 TNNT1 TXLNA USP7 YWHAG	18 interacting genes: BUB1B CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DYDC1 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C RORC SGO1 USHBP1
Entrez ID		8500	5528
HPRD ID		11451	09039
Ensembl ID		ENSG00000131626	ENSG00000112640
Uniprot IDs		A0AAG2UWZ2 B3KVS8 Q13136	Q14738
PDB IDs		1N7F	8U1X 8U89
Enriched GO Terms of Interacting Partners?		Synapse Organization Presynaptic Active Zone Cell Junction Organization Maintenance Of Synapse Structure Presynaptic Active Zone Organization Presynaptic Active Zone Cytoplasmic Component Cell Junction Maintenance Transmembrane Receptor Protein Tyrosine Phosphatase Activity Synapse Presynaptic Membrane Cellular Component Maintenance Synaptic Membrane Adhesion Gamma-tubulin Binding Protein Tyrosine Phosphatase Activity Modulation Of Chemical Synaptic Transmission Cell Projection Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Presynapse Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Postsynaptic Density Cytosol Phosphoprotein Phosphatase Activity Regulation Of Dendritic Spine Development Growth Cone Maintenance Of Postsynaptic Specialization Structure Cytoplasm Centrosome Inhibitory Synapse Protein Phosphatase Type 2A Complex Regulation Of Postsynaptic Density Assembly Protein Phosphatase Activator Activity Heparan Sulfate Proteoglycan Binding Protein Dephosphorylation Presynapse Organization Glutamatergic Synapse Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Postsynaptic Specialization Organization Regulation Of Axon Regeneration Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Neuron Projection Regeneration Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Plasma Membrane Raft Distribution Chondroitin Sulfate Proteoglycan Binding Slow-twitch Skeletal Muscle Fiber Contraction Structural Constituent Of Presynapse	Circadian Regulation Of Gene Expression Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Circadian Rhythm Circadian Rhythm Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Photoperiodism Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Glucocorticoid Secretion Rhythmic Process Cardiac Right Ventricle Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Sister Chromatid Cohesion Response To Blue Light Determination Of Heart Left/right Asymmetry E-box Binding Cellular Response To Radiation Cardiac Ventricle Formation Photoreceptor Activity Cartilage Morphogenesis Meiotic Sister Chromatid Cohesion Cardiac Chamber Formation Negative Regulation Of Circadian Rhythm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway DNA Damage Response Kinase Binding Positive Regulation Of Circadian Rhythm Epithelial Tube Morphogenesis Entrainment Of Circadian Clock By Photoperiod Regulation Of DNA Damage Checkpoint Apoptotic Process Involved In Morphogenesis Entrainment Of Circadian Clock Nucleus Signal Transduction In Response To DNA Damage Lipid Storage Chromatin Apoptotic Process Involved In Development Protein Serine/threonine Kinase Activity Negative Regulation Of Lipid Transport FAD Binding Protein Dimerization Activity Regulation Of Cell Cycle Phase Transition Response To Radiation Negative Regulation Of Intracellular Signal Transduction Nuclear Receptor Binding Photoreactive Repair RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Heart Tube Formation
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