SHANK2 and PEX3

		SHANK2	PEX3
Description		SH3 and multiple ankyrin repeat domains 2	peroxisomal biogenesis factor 3
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane	Nucleoplasm Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Protein-containing Complex Protein-lipid Complex
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Peroxisome Organization Protein Import Into Peroxisome Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Skin aging measurement ( 31522824)
Interacting Genes		34 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	4 interacting genes: PEX16 PEX19 SHANK2 WT1
Entrez ID		22941	8504
HPRD ID		04479	04407
Ensembl ID		ENSG00000162105	ENSG00000034693
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	P56589
PDB IDs		8ATJ 8B10	3AJB 3MK4
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse	Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Membrane Membrane Biogenesis Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Brush Border Membrane Peroxisomal Membrane Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization Peroxisome Peroxisome Membrane Targeting Sequence Binding Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Protein Targeting Establishment Of Protein Localization To Membrane Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Synaptic Receptor Adaptor Activity Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Protein To Membrane Docking S-shaped Body Morphogenesis Regulation Of Female Gonad Development Metanephric Mesenchyme Development Protein Localization To Membrane Diaphragm Development Positive Regulation Of Male Gonad Development Cardiac Muscle Cell Fate Commitment Establishment Of Protein Localization To Organelle Protein Carrier Chaperone Peroxisome Fission Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Neurofilament Podocyte Differentiation Nephron Tubule Morphogenesis Muscle Cell Fate Commitment C2H2 Zinc Finger Domain Binding Protein Import Into Peroxisome Matrix Metanephric Epithelium Development
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