BTG2 and SKP2

Number of citations of the paper that reports this interaction (PubMedID 22975506)
0

Data Source:
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		BTG2	SKP2
Description		BTG anti-proliferation factor 2	S-phase kinase associated protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Damage Response Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Response To Mechanical Stimulus Anterior/posterior Pattern Specification Negative Regulation Of Translation Dentate Gyrus Development Central Nervous System Neuron Development Neuron Differentiation Neuron Projection Development Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Response To Electrical Stimulus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Neural Precursor Cell Proliferation Cellular Response To Phorbol 13-acetate 12-myristate	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Double-strand Break Processing Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 27863252 28957414 32888494)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 27863252 32888494)
Interacting Genes		17 interacting genes: CCNB1 CDK1 CNOT7 CNOT8 HOXB9 HOXC8 MAPK14 MAPK3 PICK1 PIN1 PRKCA PRMT1 SKP2 SMAD1 SMAD9 SRA1 TNFRSF4	68 interacting genes: ACE2 AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDK2 CDK9 CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NHERF1 NLK NUDT1 ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR1A POLR2A PSMD9 PTK2 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 SQSTM1 STK11 TAL1 TCF3 TLE5 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		7832	6502
HPRD ID		03357	03256
Ensembl ID		ENSG00000159388	ENSG00000145604
Uniprot IDs		P78543	Q13309
PDB IDs		3DJU 3E9V	1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R 7LUO 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Cyclin B1-CDK1 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Transcription By RNA Polymerase II Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Heart Growth Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Metabolic Process Intracellular Signaling Cassette Positive Regulation Of Organ Growth Regulation Of MRNA Metabolic Process CCR4-NOT Core Complex G2/M Transition Of Mitotic Cell Cycle Mitogen-activated Protein Kinase P38 Binding SMAD Protein Complex Nucleus Cytosol Cell Cycle G2/M Phase Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Heteromeric SMAD Protein Complex Regulation Of MRNA Stability Response To Mechanical Stimulus Regulation Of Heart Growth Ventricular Cardiac Muscle Cell Development Nucleic Acid Metabolic Process Regulation Of RNA Stability Mitotic Nuclear Membrane Disassembly Poly(A)-specific Ribonuclease Activity G1/S Transition Of Mitotic Cell Cycle	Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G1/S Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Biosynthetic Process Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Differentiation
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