SKP2 and DDB1

Number of citations of the paper that reports this interaction (PubMedID 16537899)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SKP2	DDB1
Description		S-phase kinase associated protein 2	damage specific DNA binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleic Acid Binding DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Double-strand Break Processing Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	DNA Repair Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spindle Assembly Involved In Female Meiosis Proteasomal Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Viral Release From Host Cell Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Negative Regulation Of Developmental Process Biological Process Involved In Interaction With Symbiont Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway UV-damage Excision Repair Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Reproductive Process
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 27863252 32888494)
Interacting Genes		68 interacting genes: ACE2 AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDK2 CDK9 CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NHERF1 NLK NUDT1 ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR1A POLR2A PSMD9 PTK2 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 SQSTM1 STK11 TAL1 TCF3 TLE5 TRIM21 UBB VHL WEE1 YWHAB YY1	54 interacting genes: ABL1 ANXA1 BCAS3 BRAP BRWD3 CCNK CDK12 CNOT2 COPS5 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MTA2 MUS81 PIN1 POLH PPDPF PTEN RASSF1 RBBP4 RBBP7 RNF26 SALL2 SHANK3 SIN3A SKP2 SNAI1 STAT1 SUPT3H TBL1X TBL1XR1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZEB2 ZNF277
Entrez ID		6502	1642
HPRD ID		03256	10952
Ensembl ID		ENSG00000145604	ENSG00000167986
Uniprot IDs		Q13309	Q16531
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R 7LUO 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4	2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML 6XK9 6ZUE 6ZX9 7LPS 7OKQ 7OO3 7OOB 7OOP 7OPC 7OPD 7U8F 7UKN 7V7B 7V7C 7ZN7 7ZNN 8AJM 8AJN 8AJO 8B3D 8B3F 8B3G 8B3I 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G46 8G66 8OIZ 8OJH 8OV6 8QH5 8ROX 8ROY 8T9A 8TL6 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 8WQR 9BBE 9BBG 9BBH 9BBI 9BZ0 9DHD 9DJT 9DJX 9DQD 9EJQ 9ER2 9FD2 9FJX 9FMR
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G1/S Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Biosynthetic Process Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Differentiation	Cul4-RING E3 Ubiquitin Ligase Complex Nucleoplasm Nucleus Regulation Of Transcription By RNA Polymerase II Cul4A-RING E3 Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Complex DNA Metabolic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle DNA Binding Response To Stress Protein Modification By Small Protein Conjugation Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Protein Ubiquitination Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Cell Fate Specification Negative Regulation Of RNA Metabolic Process Histone Binding Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process
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