SKP2 and BTG1

Number of citations of the paper that reports this interaction (PubMedID 22975506)
0

Data Source:
BioGRID (pull down)

		SKP2	BTG1
Description		S-phase kinase associated protein 2	BTG anti-proliferation factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Transcription Coregulator Activity Protein Binding Enzyme Binding Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Double-strand Break Processing Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Regulation Of DNA-templated Transcription Response To Oxidative Stress Spermatogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cell Migration Negative Regulation Of Cell Growth Response To Peptide Hormone Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Fibroblast Apoptotic Process
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation	FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 27863252 32888494)	Heart failure ( 20445134) Metabolite levels ( 23823483) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		68 interacting genes: ACE2 AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDK2 CDK9 CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NHERF1 NLK NUDT1 ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR1A POLR2A PSMD9 PTK2 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 SQSTM1 STK11 TAL1 TCF3 TLE5 TRIM21 UBB VHL WEE1 YWHAB YY1	16 interacting genes: CCNA2 CDKN2D CNOT7 CNOT8 FADD GRB2 HOXB9 NCK2 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6
Entrez ID		6502	694
HPRD ID		03256	15912
Ensembl ID		ENSG00000145604	ENSG00000133639
Uniprot IDs		Q13309	P62324 Q6IBC8
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R 7LUO 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G1/S Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Biosynthetic Process Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Differentiation	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Female Courtship Behavior Positive Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Thyroid Hormone Binding Positive Regulation Of Lymphocyte Activation MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway CCR4-NOT Core Complex Protein-containing Complex Binding Macromolecule Metabolic Process Nuclear Receptor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Activation MRNA Transcription Regulation Of Female Receptivity Female Mating Behavior Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Translation Type I Pneumocyte Differentiation Regulation Of RNA Metabolic Process DNA-templated Transcription Protein Domain Specific Binding Poly(A)-specific Ribonuclease Activity Cytosol Chromatin DNA Binding Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation CCR4-NOT Complex Nucleobase-containing Compound Biosynthetic Process Gland Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Nuclear Receptor-mediated Signaling Pathway
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