SKP2 and NLK

Number of citations of the paper that reports this interaction (PubMedID 18765672)
47

Data Source:
HPRD (in vivo)

		SKP2	NLK
Description		S-phase kinase associated protein 2	nemo like kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding SH2 Domain Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Double-strand Break Processing Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	MAPK Cascade Regulation Of DNA-templated Transcription Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Cellular Response To Stress Intracellular Signal Transduction TORC1 Signaling Protein Stabilization Protein Localization To Lysosome Cellular Response To Osmotic Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation	Ca2+ pathway
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 27863252 32888494)	Non-response to bupropion and depression ( 27622933)
Interacting Genes		68 interacting genes: ACE2 AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDK2 CDK9 CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NHERF1 NLK NUDT1 ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR1A POLR2A PSMD9 PTK2 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 SQSTM1 STK11 TAL1 TCF3 TLE5 TRIM21 UBB VHL WEE1 YWHAB YY1	27 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-1 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 NDOR1 NOTCH1 QRICH1 RCHY1 RPTOR SDR16C5 SKP2 STAT3 USP4 ZHX3
Entrez ID		6502	51701
HPRD ID		03256	17637
Ensembl ID		ENSG00000145604	ENSG00000087095
Uniprot IDs		Q13309	Q9UBE8
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R 7LUO 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G1/S Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Biosynthetic Process Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Differentiation	Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intermediate Filament Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Response To Oxygen Levels Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process T-helper 17 Type Immune Response Regulation Of Cell Development Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Cytosol Regulation Of Glial Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Development Positive Regulation Of Cell Differentiation Negative Regulation Of Interleukin-4 Production Positive Regulation Of Odontoblast Differentiation RNA Polymerase II Transcription Regulator Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Interleukin-5 Production Positive Regulation Of Neuroepithelial Cell Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Cellular Response To Stress Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Odontoblast Differentiation
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