SKP2 and SIRT4

Number of citations of the paper that reports this interaction (PubMedID 22770219)
69

Data Source:
BioGRID (pull down)

		SKP2	SIRT4
Description		S-phase kinase associated protein 2	sirtuin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Glycosyltransferase Activity Nucleotidyltransferase Activity NAD-dependent Protein Lysine Deacetylase Activity Metal Ion Binding NAD Binding Lipoamidase Activity NAD+ Binding NAD-dependent Protein Lipoamidase Activity NAD-dependent Protein Biotinidase Activity NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Double-strand Break Processing Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Regulation Of Glutamine Family Amino Acid Metabolic Process Glutamine Metabolic Process DNA Damage Response Mitochondrion Organization Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-lysine Deacetylation Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Insulin Secretion Positive Regulation Of Lipid Biosynthetic Process Cellular Response To Hypoxia Tricarboxylic Acid Metabolic Process Negative Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation	Regulation of pyruvate dehydrogenase (PDH) complex Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 27863252 32888494)	Bipolar disorder ( 31043756)
Interacting Genes		68 interacting genes: ACE2 AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDK2 CDK9 CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NHERF1 NLK NUDT1 ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR1A POLR2A PSMD9 PTK2 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 SQSTM1 STK11 TAL1 TCF3 TLE5 TRIM21 UBB VHL WEE1 YWHAB YY1	2 interacting genes: PTEN SKP2
Entrez ID		6502	23409
HPRD ID		03256	06837
Ensembl ID		ENSG00000145604	ENSG00000089163
Uniprot IDs		Q13309	Q9Y6E7
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R 7LUO 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G1/S Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Biosynthetic Process Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Differentiation	Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Smooth Muscle Cell Proliferation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Locomotor Rhythm Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Regulation Of Protein Modification Process Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Prepulse Inhibition Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Meiotic Spindle Assembly Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Myelin Maintenance Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Parental Behavior Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Cell-matrix Adhesion Synapse Maturation Negative Regulation Of Epithelial Cell Migration Postsynaptic Density Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Focal Adhesion Assembly Dendritic Spine Morphogenesis Ubiquitin-specific Protease Binding Positive Regulation Of Protein Polyubiquitination Circadian Behavior Positive Regulation Of Cell Population Proliferation Phosphatidylinositol Dephosphorylation Meiotic Spindle Organization Rhythmic Behavior
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