SKP2 and NUDT1

Number of citations of the paper that reports this interaction (PubMedID 28947420)
0

Data Source:
BioGRID (enzymatic study)

		SKP2	NUDT1
Description		S-phase kinase associated protein 2	nudix hydrolase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Binding Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity DATP Diphosphatase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides SnoRNA Binding 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Metal Ion Binding ATP Diphosphatase Activity 2-hydroxy-ATP Hydrolase Activity 2-hydroxy-dATP Hydrolase Activity N6-methyl-(d)ATP Hydrolase Activity O6-methyl-dGTP Hydrolase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Double-strand Break Processing Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Purine Nucleoside Catabolic Process DNA Repair Response To Oxidative Stress DNA Protection
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 27863252 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Dimensional psychopathology (Social) ( 29496196) Schizophrenia ( 22688191 23974872)
Interacting Genes		68 interacting genes: ACE2 AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDK2 CDK9 CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NHERF1 NLK NUDT1 ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR1A POLR2A PSMD9 PTK2 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 SQSTM1 STK11 TAL1 TCF3 TLE5 TRIM21 UBB VHL WEE1 YWHAB YY1	4 interacting genes: CFTR FMNL3 SKP2 TYW2
Entrez ID		6502	4521
HPRD ID		03256	02634
Ensembl ID		ENSG00000145604	ENSG00000106268
Uniprot IDs		Q13309	P36639
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R 7LUO 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4	1IRY 3Q93 3WHW 3ZR0 3ZR1 4C9W 4C9X 4N1T 4N1U 5ANS 5ANT 5ANU 5ANV 5ANW 5FSI 5FSK 5FSL 5FSM 5FSN 5FSO 5GHI 5GHJ 5GHM 5GHN 5GHO 5GHP 5GHQ 5NGR 5NGS 5NGT 5NHY 5OTM 5WS7 6AA3 6AA4 6AA5 6EQ2 6EQ3 6EQ4 6EQ5 6EQ6 6EQ7 6F1X 6F20 6F22 6F23 6GLE 6GLF 6GLG 6GLH 6GLI 6GLJ 6GLK 6GLL 6GLM 6GLN 6GLO 6GLP 6GLQ 6GLR 6GLS 6GLT 6GLU 6GLV 6IJY 6ILI 6IMZ 6JVF 6JVG 6JVH 6JVI 6JVJ 6JVK 6JVL 6JVM 6JVN 6JVO 6JVP 6JVQ 6JVR 6JVS 6JVT 6QVO 6US2 6US3 6US4 7ESF 7N03 7N13 8A07 8A0S 8A0T 8A34 8A3A 8I18 8I19 8I1A 8I1C 8I1D 8I1E 8I1F 8I1G 8I1H 8I1I 8I1J 8I8S 8I8T
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G1/S Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Biosynthetic Process Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Differentiation	Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding TRNA 4-demethylwyosine Alpha-amino-alpha-carboxypropyltransferase Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Cellular Response To Cell-matrix Adhesion Transepithelial Water Transport Wybutosine Biosynthetic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization TRNA Methyltransferase Activity Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity GTPase Activating Protein Binding Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Positive Regulation Of Protein Polyubiquitination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?