SMARCAL1

Description		SNF2 related chromatin remodeling annealing helicase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity ATP-dependent DNA/DNA Annealing Activity
	Biological Process	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II DNA Damage Response Replication Fork Processing T-circle Formation
Pathways
Drugs
Diseases		Schimke immunoosseous dysplasia
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter integrity (fractional anisotropy) ( 32358547)
Novel Interacting Genes		2 novel interacting genes: ACSL3 RPA2
Interacting Genes		2 interacting genes: ACSL3 RPA2
Entrez ID		50485
HPRD ID		05969
Ensembl ID		ENSG00000138375
Uniprot IDs		Q9NZC9
PDB IDs		4MQV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphatidylcholine Biosynthetic Process Medium-chain Fatty Acid-CoA Ligase Activity Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Very-low-density Lipoprotein Particle Assembly Arachidonate-CoA Ligase Activity Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Phosphatidylcholine Biosynthetic Process Long-chain Fatty Acid Import Into Cell Palmitoyl-CoA Ligase Activity Positive Regulation Of Phospholipid Biosynthetic Process Fatty Acid-CoA Ligase Activity G-rich Strand Telomeric DNA Binding Long-chain Fatty Acid-CoA Ligase Activity Lipid Import Into Cell DNA Replication Factor A Complex Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Phospholipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Plasma Lipoprotein Particle Assembly Regulation Of DNA Damage Checkpoint Protein-lipid Complex Assembly Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Telomeric DNA Binding Mismatch Repair Regulation Of Phospholipid Metabolic Process Base-excision Repair Fatty Acid Derivative Biosynthetic Process Long-chain Fatty Acid Transport Nucleotide-excision Repair Peroxisomal Membrane Positive Regulation Of Protein Localization To Plasma Membrane Damaged DNA Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Localization To Cell Periphery Fatty Acid Derivative Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Sulfur Compound Biosynthetic Process Lipid Droplet Long-chain Fatty Acid Metabolic Process Fatty Acid Transport Acyl-CoA Metabolic Process Positive Regulation Of Protein Localization To Membrane Telomere Maintenance Protein Phosphatase Binding
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