ACTA1 and VIL1

Number of citations of the paper that reports this interaction (PubMedID 3793760)
51

Data Source:
HPRD (in vitro)

		ACTA1	VIL1
Description		actin alpha 1, skeletal muscle	villin 1
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Microvillus Brush Border Actin Cytoskeleton Lamellipodium Filopodium Actin Filament Bundle Filopodium Tip Cell Projection Extracellular Exosome
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lysophosphatidic Acid Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Actin Filament Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Intestinal D-glucose Absorption Apoptotic Process Cytoskeleton Organization Actin Filament Organization Epidermal Growth Factor Receptor Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Epithelial Cell Migration Actin Filament Polymerization Actin Filament Depolymerization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Microvillus Length Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Cellular Component Biogenesis Actin Filament Severing Barbed-end Actin Filament Capping Regulation Of Actin Nucleation Actin Filament Capping Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Wound Healing Protein-containing Complex Assembly Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Lamellipodium Organization Terminal Web Assembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Adult body size ( 32376654) Estimated glomerular filtration rate ( 31152163) Height ( 31562340) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Red blood cell count ( 27863252) Waist-hip index ( 34021172)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	7 interacting genes: ACTA1 ACTG1 JAK3 PLCG1 RNF10 SRC TEX11
Entrez ID		58	7429
HPRD ID		00030	01898
Ensembl ID		ENSG00000143632	ENSG00000127831
Uniprot IDs		P68133	P09327 Q53F91
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV	1UNC 3FG7
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Actin Filament Negative Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Epithelial Cell Migration Fc Receptor Signaling Pathway Regulation Of Cell-substrate Junction Organization Basal Body Patch Regulation Of Focal Adhesion Assembly ERBB Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Meiotic Gene Conversion Structural Constituent Of Cytoskeleton ATP Binding Blood Microparticle Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell Migration Response To Peptide Positive Regulation Of Cell Motility Response To Cytokine Actomyosin Structure Organization Multicellular Organismal-level Homeostasis Negative Regulation Of Dendritic Cell Cytokine Production Response To Interleukin-9 Negative Regulation Of Immune System Process Response To Interleukin-2 Response To Interleukin-15 Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Ruffle Membrane Calcium-dependent Phospholipase C Activity Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Gene Conversion Male Meiosis Chromosome Segregation Positive Regulation Of Locomotion Regulation Of Apoptotic Process Regulation Of Transepithelial Transport Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Programmed Cell Death Cellular Response To Progesterone Stimulus Enzyme-linked Receptor Protein Signaling Pathway Nucleotide Binding Lamellipodium Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Protein Localization To Bicellular Tight Junction Structural Constituent Of Postsynaptic Actin Cytoskeleton
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?