ACTA1 and PPP1R9B

Number of citations of the paper that reports this interaction (PubMedID 12417592)
0

Data Source:
BioGRID (pull down)

		ACTA1	PPP1R9B
Description		actin alpha 1, skeletal muscle	protein phosphatase 1 regulatory subunit 9B
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Filopodium Dendrite Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Spine Neck Dendritic Spine Head Synapse Anchoring Junction Spine Apparatus Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Plasma Membrane Bounded Cell Projection Cytoplasmic Side Of Dendritic Spine Plasma Membrane
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Actin Binding Protein Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Kinase Binding D2 Dopamine Receptor Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Regulation Of Cell Growth By Extracellular Stimulus Response To Amphetamine Developmental Process Involved In Reproduction Actin Filament Organization Regulation Of Exit From Mitosis Nervous System Development Learning RNA Splicing Response To Xenobiotic Stimulus Dendrite Development Cell Migration Calcium-mediated Signaling Hippocampus Development Cerebral Cortex Development Actin Filament Depolymerization Cell Differentiation Negative Regulation Of Cell Growth Neuron Projection Development Response To Estradiol Response To Prostaglandin E Response To Nicotine Response To Immobilization Stress Regulation Of Cell Population Proliferation Response To Amino Acid Filopodium Assembly Response To Steroid Hormone Regulation Of Cell Cycle Male Mating Behavior Reproductive System Development Cellular Response To Morphine Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Regulation Of Postsynapse Assembly Cellular Response To Peptide Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Actin Cytoskeleton Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Actin Cortical Patch Response To Kainic Acid Response To L-phenylalanine Derivative Protein Localization To Cell Periphery Regulation Of Opioid Receptor Signaling Pathway
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Platelet distribution width ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	29 interacting genes: ACTA1 ACTN2 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 ITGB8 LRRC7 MAPK1 MECOM PPP1CA PPP1R2 PPP1R9A PRKACA RB1 RBL1 RBL2 RGS2 RPS6KB1 SHANK3 TGOLN2 TIAM1
Entrez ID		58	84687
HPRD ID		00030	04506
Ensembl ID		ENSG00000143632	ENSG00000108819
Uniprot IDs		P68133	Q96SB3
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Adrenergic Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Catecholamine Secretion Alpha2-adrenergic Receptor Activity Regulation Of Muscle System Process Intracellular Signaling Cassette Regulation Of Blood Circulation G Protein-coupled Receptor Activity Signal Transduction Regulation Of System Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Negative Regulation Of Epinephrine Secretion Regulation Of Vasoconstriction Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Amine Transport System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Catecholamine Secretion Regulation Of Biological Quality Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Norepinephrine Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Developmental Process Phospholipase C-activating Adrenergic Receptor Signaling Pathway Cholecystokinin Receptor Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Hormone Secretion Dendritic Spine Positive Regulation Of Signal Transduction Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Intracellular Signal Transduction Alpha1-adrenergic Receptor Activity Cholecystokinin Signaling Pathway Regulation Of Insulin Secretion ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization
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