ACTA1 and AJUBA

Number of citations of the paper that reports this interaction (PubMedID 12417594)
0

Data Source:
HPRD (in vitro, in vivo)

		ACTA1	AJUBA
Description		actin alpha 1, skeletal muscle	ajuba LIM protein
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	P-body Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Membrane Lamellipodium Anchoring Junction
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Protein Kinase Activator Activity Alpha-catenin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of DNA-templated Transcription Cytoskeleton Organization Cell Adhesion Intracellular Protein Localization Positive Regulation Of Biosynthetic Process Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Assembly Regulation Of Cell Migration Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Protein-containing Complex Assembly MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Hippo Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Glycerophospholipid Biosynthetic Process Focal Adhesion Assembly Regulation Of Cellular Response To Hypoxia
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of PLK1 Activity at G2/M Transition Activation of anterior HOX genes in hindbrain development during early embryogenesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Insular cortex volume ( 31530798) Macular thickness ( 30535121) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Spatial processing ( 31596458)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	24 interacting genes: ACTA1 AURKA AURKAIP1 AURKB BCAR1 CATSPER1 CREB5 CTNNA1 FARS2 GFI1B GRB2 ITSN1 LATS2 LCK LGALS14 PIN1 RPA1 SLC1A2 TEKT3 TFAP4 TSG101 WEE2-AS1 ZNF512B ZNF541
Entrez ID		58	84962
HPRD ID		00030	16426
Ensembl ID		ENSG00000143632	ENSG00000129474
Uniprot IDs		P68133	Q96IF1
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	B Cell Receptor Signaling Pathway Chromosome Passenger Complex Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Lamellipodium Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Cytokinesis Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Meiotic Cell Cycle Spindle Midzone Negative Regulation Of Protein Phosphorylation Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Phosphorylation Protein Serine/threonine/tyrosine Kinase Activity Nucleus Regulation Of Protein Localization To Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Nuclear Division Cis-trans Isomerase Activity Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Phase Transition Spindle Pole Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Brood Size Outer Acrosomal Membrane Spindle Microtubule Negative Regulation Of Phosphate Metabolic Process T Cell Costimulation Centrosome Regulation Of Cell Division Regulation Of Protein Phosphorylation
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