VIL1

Description		villin 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Microvillus Brush Border Actin Cytoskeleton Lamellipodium Filopodium Actin Filament Bundle Filopodium Tip Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lysophosphatidic Acid Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Actin Filament Binding
	Biological Process	Intestinal D-glucose Absorption Apoptotic Process Cytoskeleton Organization Actin Filament Organization Epidermal Growth Factor Receptor Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Epithelial Cell Migration Actin Filament Polymerization Actin Filament Depolymerization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Microvillus Length Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Cellular Component Biogenesis Actin Filament Severing Barbed-end Actin Filament Capping Regulation Of Actin Nucleation Actin Filament Capping Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Wound Healing Protein-containing Complex Assembly Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Lamellipodium Organization Terminal Web Assembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Lamellipodium Morphogenesis
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Estimated glomerular filtration rate ( 31152163) Height ( 31562340) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Red blood cell count ( 27863252) Waist-hip index ( 34021172)
Novel Interacting Genes		7 novel interacting genes: ACTA1 ACTG1 JAK3 PLCG1 RNF10 SRC TEX11
Interacting Genes		7 interacting genes: ACTA1 ACTG1 JAK3 PLCG1 RNF10 SRC TEX11
Entrez ID		7429
HPRD ID		01898
Ensembl ID		ENSG00000127831
Uniprot IDs		P09327 Q53F91
PDB IDs		1UNC 3FG7
Enriched GO Terms of Interacting Partners?		Actin Filament Negative Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Epithelial Cell Migration Fc Receptor Signaling Pathway Regulation Of Cell-substrate Junction Organization Basal Body Patch Regulation Of Focal Adhesion Assembly ERBB Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Meiotic Gene Conversion Structural Constituent Of Cytoskeleton ATP Binding Blood Microparticle Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell Migration Response To Peptide Positive Regulation Of Cell Motility Response To Cytokine Actomyosin Structure Organization Multicellular Organismal-level Homeostasis Negative Regulation Of Dendritic Cell Cytokine Production Response To Interleukin-9 Negative Regulation Of Immune System Process Response To Interleukin-2 Response To Interleukin-15 Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Ruffle Membrane Calcium-dependent Phospholipase C Activity Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Gene Conversion Male Meiosis Chromosome Segregation Positive Regulation Of Locomotion Regulation Of Apoptotic Process Regulation Of Transepithelial Transport Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Programmed Cell Death Cellular Response To Progesterone Stimulus Enzyme-linked Receptor Protein Signaling Pathway Nucleotide Binding Lamellipodium Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Protein Localization To Bicellular Tight Junction Structural Constituent Of Postsynaptic Actin Cytoskeleton
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