ACTA1 and MACF1

Number of citations of the paper that reports this interaction (PubMedID 10601340)
55

Data Source:
HPRD (in vitro, in vivo)

		ACTA1	MACF1
Description		actin alpha 1, skeletal muscle	microtubule actin crosslinking factor 1
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Cell Leading Edge Ruffle Membrane Cell Projection
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Cadherin Binding Metal Ion Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Projection Organization Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Multicellular Organismal Process Regulation Of Focal Adhesion Assembly Establishment Of Protein Localization To Membrane Regulation Of Neuron Projection Arborization
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 20686565 25961943) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 27189021 28869590 29358691 32499647 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Ventral thalamic nuclei volume ( 34006833)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	38 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DSCAM DSCR9 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN LCOR MAPK9 MAPRE1 MTNR1B NRCAM NRIP1 NRXN1 NRXN2 PCNT PKNOX1 PLXND1 PRKCD RIPK4 SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC USP7
Entrez ID		58	23499
HPRD ID		00030	09750
Ensembl ID		ENSG00000143632	ENSG00000127603
Uniprot IDs		P68133	H3BPE1 O94854 Q6ZSD7 Q9UPN3
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV	4Z6G 5VE9 5X57
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Positive Regulation Of Cellular Component Organization Vocal Learning Positive Regulation Of Axonogenesis Observational Learning Positive Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Synapse Assembly Neuron Recognition Auditory Behavior Mechanosensory Behavior Social Behavior Vocalization Behavior Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Regulation Of Axonogenesis Cell Junction Assembly Neuron Projection Morphogenesis Positive Regulation Of Nervous System Development Regulation Of Axon Extension Glutamatergic Synapse Negative Regulation Of Filopodium Assembly Cell Projection Morphogenesis Anatomical Structure Morphogenesis Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Family Protein Binding Angiogenesis Postsynaptic Density Protein 95 Clustering Neuron Projection Development Positive Regulation Of Axon Extension Modulation Of Chemical Synaptic Transmission Neurotransmitter Secretion Postsynaptic Membrane Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Neurogenesis Regulation Of Filopodium Assembly Regulation Of Cell Projection Assembly Synapse Cell Recognition Postsynaptic Membrane Organization Axon Synapse Organization Presynaptic Membrane Positive Regulation Of Intracellular Transport Neuronal Ion Channel Clustering Regulation Of Postsynapse Organization Cilium Assembly
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