ACTA1 and ITPKA

Number of citations of the paper that reports this interaction (PubMedID 11468283)
0

Data Source:
HPRD (in vitro)

		ACTA1	ITPKA
Description		actin alpha 1, skeletal muscle	inositol-trisphosphate 3-kinase A
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Nucleus Cytoplasm Cytosol Cytoskeleton Dendritic Spine Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Nucleotide Binding Inositol Hexakisphosphate Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Transferase Activity Small GTPase Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Inositol Metabolic Process Signal Transduction Actin Cytoskeleton Organization Inositol Phosphate Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Synaptic Plasticity Response To Calcium Ion Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Dendritic Spine Maintenance Modification Of Postsynaptic Actin Cytoskeleton
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Synthesis of IP3 and IP4 in the cytosol
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B	Inositol 1,3,4,5-Tetrakisphosphate 1D-myo-inositol 1,4,5-trisphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 23128233)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	8 interacting genes: ACTA1 CALM1 CAMK2A CAMK2B ERBB2 ITSN2 PRKACA PRKCA
Entrez ID		58	3706
HPRD ID		00030	00941
Ensembl ID		ENSG00000143632	ENSG00000137825
Uniprot IDs		P68133	P23677
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV	1W2C 1W2D 1W2F 4UPU 8PP8 8PP9 8PPA 8PPB 8PPC 8PPD 8PPE 8PPF 8PPG 8PPH 8PPI 8PPJ
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Phosphorylation Protein Phosphorylation Long-term Synaptic Potentiation Regulation Of Calcium Ion Transport Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Kinase Activity Regulation Of Muscle System Process Kinase Activity ATP Binding Regulation Of Metal Ion Transport Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Nucleotide Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Modulation Of Chemical Synaptic Transmission Calcium/calmodulin-dependent Protein Kinase Activity Developmental Process Cellular Response To Interferon-beta Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cellular Localization Regulation Of System Process Myelin Sheath Regulation Of Synaptic Plasticity Cytosol Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Interferon-beta Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Centrosome Phosphate-containing Compound Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Presynaptic Endocytosis Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Neuron Migration Sperm Midpiece Regulation Of Biological Quality Sarcomere Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Neuronal Synaptic Plasticity Protein Modification Process Positive Regulation Of Establishment Of Protein Localization Intracellular Signaling Cassette Regulation Of Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Transferase Activity
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