ACTA1 and SCIN

Number of citations of the paper that reports this interaction (PubMedID 12438125)
0

Data Source:
BioGRID (pull down)

		ACTA1	SCIN
Description		actin alpha 1, skeletal muscle	scinderin
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Podosome Cytoplasm Cytoskeleton Brush Border Cell Cortex Actin Cytoskeleton Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Phosphatidylserine Binding Actin Binding Calcium Ion Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Central Nervous System Development Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Calcium-ion Regulated Exocytosis Cell Projection Assembly Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Secretion Positive Regulation Of Actin Nucleation Actin Filament Capping
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Height ( 31562340) Metabolite levels ( 23823483) Small cell lung carcinoma ( 28604730)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	4 interacting genes: ACTA1 ACTC1 ACTG1 UBAP2L
Entrez ID		58	85477
HPRD ID		00030	11539
Ensembl ID		ENSG00000143632	ENSG00000006747
Uniprot IDs		P68133	Q9Y6U3
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV	3FG6 5A1K 5A1M
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Actin Filament Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Blood Microparticle Myosin Binding Actin Cytoskeleton Sarcomere Filopodium Cell Body Structural Constituent Of Cytoskeleton Basal Body Patch Actomyosin Structure Organization Lamellipodium Muscle Contraction Regulation Of Transepithelial Transport Muscle System Process Actin Filament Organization Positive Regulation Of Gene Expression Cytoplasmic Actin-based Contraction Involved In Cell Motility Protein Localization To Bicellular Tight Junction Dense Body Morphogenesis Of A Polarized Epithelium Membraneless Organelle Assembly Structural Constituent Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Stress Granule Assembly ATP Binding Striated Muscle Thin Filament Cytoskeleton Extracellular Space Profilin Binding Actin Cytoskeleton Organization Regulation Of Stress Granule Assembly Hydrolase Activity Actin Filament-based Process Tissue Morphogenesis Focal Adhesion Cardiac Myofibril Assembly Nucleotide Binding Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding Protein Localization To Cell-cell Junction Calyx Of Held Supramolecular Fiber Organization Multicellular Organismal-level Homeostasis Postsynaptic Cytoskeleton Organization Heart Contraction Regulation Of Synaptic Vesicle Endocytosis Skeletal Muscle Fiber Development Extracellular Exosome Myofibril Assembly
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