ITPKA

Description		inositol-trisphosphate 3-kinase A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Dendritic Spine Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Inositol Hexakisphosphate Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Transferase Activity Small GTPase Binding
	Biological Process	Inositol Metabolic Process Signal Transduction Actin Cytoskeleton Organization Inositol Phosphate Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Synaptic Plasticity Response To Calcium Ion Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Dendritic Spine Maintenance Modification Of Postsynaptic Actin Cytoskeleton
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs		Inositol 1,3,4,5-Tetrakisphosphate 1D-myo-inositol 1,4,5-trisphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 23128233)
Novel Interacting Genes		8 novel interacting genes: ACTA1 CALM1 CAMK2A CAMK2B ERBB2 ITSN2 PRKACA PRKCA
Interacting Genes		8 interacting genes: ACTA1 CALM1 CAMK2A CAMK2B ERBB2 ITSN2 PRKACA PRKCA
Entrez ID		3706
HPRD ID		00941
Ensembl ID		ENSG00000137825
Uniprot IDs		P23677
PDB IDs		1W2C 1W2D 1W2F 4UPU 8PP8 8PP9 8PPA 8PPB 8PPC 8PPD 8PPE 8PPF 8PPG 8PPH 8PPI 8PPJ
Enriched GO Terms of Interacting Partners?		Phosphorylation Protein Phosphorylation Long-term Synaptic Potentiation Regulation Of Calcium Ion Transport Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Kinase Activity Regulation Of Muscle System Process Kinase Activity ATP Binding Regulation Of Metal Ion Transport Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Nucleotide Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Modulation Of Chemical Synaptic Transmission Calcium/calmodulin-dependent Protein Kinase Activity Developmental Process Cellular Response To Interferon-beta Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cellular Localization Regulation Of System Process Myelin Sheath Regulation Of Synaptic Plasticity Cytosol Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Interferon-beta Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Centrosome Phosphate-containing Compound Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Presynaptic Endocytosis Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Neuron Migration Sperm Midpiece Regulation Of Biological Quality Sarcomere Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Neuronal Synaptic Plasticity Protein Modification Process Positive Regulation Of Establishment Of Protein Localization Intracellular Signaling Cassette Regulation Of Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Transferase Activity
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