MAPK15 and GABARAP

Number of citations of the paper that reports this interaction (PubMedID 22948227)
75

Data Source:
BioGRID (pull down, affinity chromatography technology)

		MAPK15	GABARAP
Description		mitogen-activated protein kinase 15	GABA type A receptor-associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Autophagosome Golgi Apparatus Centriole Spindle Cytoskeleton Cell-cell Junction Bicellular Tight Junction Axoneme Cytoplasmic Vesicle Ciliary Basal Body Cell Projection Anchoring Junction Meiotic Spindle	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Serine Kinase Activity	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	MAPK Cascade Regulation Of COPII Vesicle Coating DNA Damage Response Endoplasmic Reticulum Organization Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Negative Regulation Of Cell Migration Positive Regulation Of Telomere Maintenance Cellular Response To Stress Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Dopamine Uptake Regulation Of Cilium Assembly Protein Localization To Ciliary Transition Zone Positive Regulation Of Metaphase/anaphase Transition Of Meiosis I Positive Regulation Of Spindle Assembly	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination
Pathways			Macroautophagy TBC/RABGAPs
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		9 interacting genes: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 RHEB SRC TGFB1I1	75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28
Entrez ID		225689	11337
HPRD ID		16867	05496
Ensembl ID		ENSG00000181085	ENSG00000170296
Uniprot IDs		Q8TD08	O95166 Q6IAW1
PDB IDs			1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Cellular Response To Nutrient Levels Cellular Response To Nitrogen Starvation Autophagosome Assembly Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Autophagosome Organization Phosphatidylethanolamine Binding Regulation Of Proteolysis GABA Receptor Binding Positive Regulation Of Multicellular Organismal Process Macroautophagy Response To Nutrient Levels Vacuole Organization Signal Transduction Regulation Of Bone Resorption T Cell Costimulation Regulation Of Bone Remodeling Oligodendrocyte Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Beta-tubulin Binding Autophagosome Maturation Negative Regulation Of Cell Adhesion Nuclear Glucocorticoid Receptor Activity Cytoskeleton Chemical Synaptic Transmission Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Metalloendopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Autophagy Mitophagy Autophagosome Membrane Cellular Response To Hormone Stimulus Cytosol Morphogenesis Of An Epithelium Trans-synaptic Signaling Response To Transforming Growth Factor Beta Synaptic Signaling Autophagy Of Mitochondrion Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Tissue Remodeling Autophagosome Cellular Response To Steroid Hormone Stimulus TOR Signaling Positive Regulation Of TOR Signaling Tissue Morphogenesis Protein-disulfide Reductase (glutathione) Activity	Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation
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