GABARAP and ATG7

Number of citations of the paper that reports this interaction (PubMedID 25126726)
63

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		GABARAP	ATG7
Description		GABA type A receptor-associated protein	autophagy related 7
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	Phagophore Assembly Site Extracellular Region Cytoplasm Cytosol Axoneme Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Protein Binding Ubiquitin-like Modifier Activating Enzyme Activity Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	Autophagosome Assembly Mitophagy Protein Lipidation Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Positive Regulation Of Catabolic Process Protein Transport Macroautophagy Positive Regulation Of Protein Modification Process Response To Nutrient Levels Protein Modification By Small Protein Conjugation Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Defense Response To Virus Regulation Of Macromolecule Metabolic Process Cellular Response To Hyperoxia Regulation Of Primary Metabolic Process
Pathways		Macroautophagy TBC/RABGAPs	Macroautophagy Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF1 fusions Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Aspartate aminotransferase levels ( 33547301) Body fat mass ( 28552196) Body size at age 10 ( 32376654) Circulating chemerin levels ( 25521368) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) Relative hand skill in reading disability ( 24068947) Small vessel stroke ( 29123153) Systolic blood pressure ( 30578418 27618452 27618447) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	11 interacting genes: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B TRIM7
Entrez ID		11337	10533
HPRD ID		05496	12293
Ensembl ID		ENSG00000170296	ENSG00000197548
Uniprot IDs		O95166 Q6IAW1	B3KQM6 O95352
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Autophagy Of Mitochondrion Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagy Mitophagy Autophagosome Protein-containing Complex Disassembly Organelle Assembly Atg12 Transferase Activity Phospholipid Binding Atg8-family Ligase Activity Cellular Response To Starvation Atg12-Atg5-Atg16 Complex Response To Stress Response To Starvation Microtubule Binding Cellular Response To Nutrient Levels Cellular Component Assembly Glycophagy Ubiquitin Protein Ligase Binding Catabolic Process GABA Receptor Binding Response To Lead Ion Ubiquitin-like Protein Transferase Activity Cytosol Glycogen Catabolic Process Cellular Response To Copper Ion Nucleophagy Protein-containing Complex Organization Cytoplasmic Vesicle Polysaccharide Catabolic Process Cellular Response To Stress Response To Nutrient Levels Response To Copper Ion Organelle Organization Beta-tubulin Binding Organelle Membrane Endomembrane System Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Atg8-family Conjugating Enzyme Activity
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