GABARAP and STK3

Number of citations of the paper that reports this interaction (PubMedID 31857374)
66

Data Source:
BioGRID (pull down, pull down)

		GABARAP	STK3
Description		GABA type A receptor-associated protein	serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Macroautophagy TBC/RABGAPs	Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A
Entrez ID		11337	6788
HPRD ID		05496	05433
Ensembl ID		ENSG00000170296	ENSG00000104375
Uniprot IDs		O95166 Q6IAW1	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity
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