GABARAP and MLH1

Number of citations of the paper that reports this interaction (PubMedID 20706999)
0

Data Source:
BioGRID (two hybrid)

		GABARAP	MLH1
Description		GABA type A receptor-associated protein	mutL homolog 1
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Chiasma Late Recombination Nodule Membrane Nuclear Lumen Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress DNA Damage Response Male Meiosis Chromosome Segregation Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Meiotic Metaphase I Homologous Chromosome Alignment Meiotic Chromosome Segregation Meiotic Telomere Clustering Homologous Chromosome Segregation Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly Meiotic Cell Cycle
Pathways		Macroautophagy TBC/RABGAPs	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination
Drugs
Diseases			Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer Endometrial Cancer
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Alanine aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Liver enzyme levels (alanine transaminase) ( 33972514) Platelet distribution width ( 32888494) Proximal colorectal cancer ( 33632709) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	140 interacting genes: - ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ALDOB ANXA6 AP1B1 AP2B1 APRT ARAF ASS1 ATF2 BAAT BLM BRCA1 BTBD2 C9orf152 CAB39L CAPN5 CASP3 CBY2 CCDC180 CCDC33 CCDC74B CDCA7L CDKL5 CEP126 CEP76 CKAP4 CKB CTSV CYLC2 DDX47 EEF1G EEF2 EIF2A ELP6 ENKD1 EXO1 EXOC3 FAM228A FAM50B FAM90A1 FBXO32 FCGBP FLNB FRAT2 FRMD6 GABARAP GPX1 GSTP1 HDAC6 IGKC ISY1 KPNA2 KPNA5 KPRP LEF1 LGALS4 LUC7L3 LY96 MAGEA8 MAP2K6 MBD3L1 MBD4 MLH3 MORN3 MPG MSH2 MSH3 MSH4 MSH5 MUC2 MYC MYL6 MYOG NANOS3 NDRG1 NELFA NME4 NT5C3B ORC4 PARP12 PARVA PCNA PER2 PIP4K2B PMS1 PMS2 PPP1R13B PPP2CB PRR5L PSMA1 PTGDS PTPN3 PTPRH RAD23B RAD9A RADX RAPGEFL1 RBM48 RSPH3 SEC61A1 SELENBP1 SERPINF1 SMAD1 SPATA8 SQSTM1 STAP2 STX17 SYF2 TASOR2 TDRD7 TFAP2D TLE5 TRIM23 TRIM29 TRMO TSGA13 TXN TXN2 U2AF1 UBOX5 VAMP8 XPA ZBED1 ZC3H11A ZER1 ZFP57 ZFP90 ZMAT5 ZNF177 ZNF212 ZNF474 ZNF559-ZNF177 ZNF774
Entrez ID		11337	4292
HPRD ID		05496	00390
Ensembl ID		ENSG00000170296	ENSG00000076242
Uniprot IDs		O95166 Q6IAW1	A0A087WX20 A0A669KAW3 A0AAQ5BGN3 A0AAQ5BGZ2 H0Y818 P40692 Q59EG3
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A	3RBN 4P7A 5U5P 6WBA 6WBB 6WBC 7M60
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Mismatch Repair Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Cellular Response To Stress Apoptotic Signaling Pathway Response To Estradiol DNA Damage Response Dinucleotide Insertion Or Deletion Binding Intrinsic Apoptotic Signaling Pathway Response To Corticosteroid DNA Repair Mismatch Repair Complex DNA Metabolic Process Protein Binding Response To Glucocorticoid Damaged DNA Binding Response To Hydrogen Peroxide Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Response To Dexamethasone Mitotic DNA Integrity Checkpoint Signaling Somatic Cell DNA Recombination Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Response To Reactive Oxygen Species MutSbeta Complex Dinucleotide Repeat Insertion Binding Response To Steroid Hormone Nucleus Response To Stress Somatic Hypermutation Of Immunoglobulin Genes DNA Recombination DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Fructose-bisphosphate Aldolase Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Single Guanine Insertion Binding MutLalpha Complex Response To Oxidative Stress Cellular Response To Corticosteroid Stimulus Mucus Secretion Response To Radiation Single-stranded DNA Binding P53 Binding Response To UV Mitotic Intra-S DNA Damage Checkpoint Signaling Signal Sequence Binding Guanine/thymine Mispair Binding Satellite DNA Binding Somatic Diversification Of Immunoglobulins
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