MAPK15 and RHEB

		MAPK15	RHEB
Description		mitogen-activated protein kinase 15	Ras homolog, mTORC1 binding
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Autophagosome Golgi Apparatus Centriole Spindle Cytoskeleton Cell-cell Junction Bicellular Tight Junction Axoneme Cytoplasmic Vesicle Ciliary Basal Body Cell Projection Anchoring Junction Meiotic Spindle	Golgi Membrane Spliceosomal Complex Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Serine Kinase Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding
	Biological Process	MAPK Cascade Regulation Of COPII Vesicle Coating DNA Damage Response Endoplasmic Reticulum Organization Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Negative Regulation Of Cell Migration Positive Regulation Of Telomere Maintenance Cellular Response To Stress Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Dopamine Uptake Regulation Of Cilium Assembly Protein Localization To Ciliary Transition Zone Positive Regulation Of Metaphase/anaphase Transition Of Meiosis I Positive Regulation Of Spindle Assembly	Autophagosome Assembly Cytoplasmic Translation Signal Transduction Small GTPase-mediated Signal Transduction Response To Virus Negative Regulation Of Autophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of TORC1 Signaling Regulation Of Type B Pancreatic Cell Development
Pathways			Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib	Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Obesity-related traits ( 23251661)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 RHEB SRC TGFB1I1	35 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CENPE CREB3 ECSIT FKBP8 HTT MAPK15 MTOR NCAM1 NOS3 PDE6D PIGB PLD1 PPP1R3C PSEN1 PSEN2 PTPRN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID		225689	6009
HPRD ID		16867	03188
Ensembl ID		ENSG00000181085	ENSG00000106615
Uniprot IDs		Q8TD08	A0A090N900 Q15382
PDB IDs			1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Cellular Response To Nutrient Levels Cellular Response To Nitrogen Starvation Autophagosome Assembly Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Autophagosome Organization Phosphatidylethanolamine Binding Regulation Of Proteolysis GABA Receptor Binding Positive Regulation Of Multicellular Organismal Process Macroautophagy Response To Nutrient Levels Vacuole Organization Signal Transduction Regulation Of Bone Resorption T Cell Costimulation Regulation Of Bone Remodeling Oligodendrocyte Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Beta-tubulin Binding Autophagosome Maturation Negative Regulation Of Cell Adhesion Nuclear Glucocorticoid Receptor Activity Cytoskeleton Chemical Synaptic Transmission Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Metalloendopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Autophagy Mitophagy Autophagosome Membrane Cellular Response To Hormone Stimulus Cytosol Morphogenesis Of An Epithelium Trans-synaptic Signaling Response To Transforming Growth Factor Beta Synaptic Signaling Autophagy Of Mitochondrion Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Tissue Remodeling Autophagosome Cellular Response To Steroid Hormone Stimulus TOR Signaling Positive Regulation Of TOR Signaling Tissue Morphogenesis Protein-disulfide Reductase (glutathione) Activity	Intracellular Signal Transduction Regulation Of Autophagy Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Response To Nutrient Levels Positive Regulation Of Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Translation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Nutrient Levels Regulation Of Autophagy Of Mitochondrion Regulation Of Translational Initiation Protein Metabolic Process Apoptotic Process Positive Regulation Of Cell Communication Programmed Cell Death Cell Death Cytoplasmic Translation Response To Starvation Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Golgi Apparatus Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Autophagosome Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Starvation Negative Regulation Of Signal Transduction Autophagosome Organization Regulation Of Apoptotic Process Negative Regulation Of Autophagy Regulation Of Mitophagy Protein Catabolic Process Thymus Development Regulation Of Intracellular Signal Transduction
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