GABARAP and CUL3

Number of citations of the paper that reports this interaction (PubMedID 25684205)
0

Data Source:
BioGRID (pull down)

		GABARAP	CUL3
Description		GABA type A receptor-associated protein	cullin 3
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Motile Cilium Sperm Flagellum Cell Projection Extracellular Exosome Mitotic Spindle Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitotic Cell Cycle Cell Morphogenesis In Utero Embryonic Development Kidney Development Trophectodermal Cellular Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Response To Stress Inflammatory Response Response To Oxidative Stress Mitotic Metaphase Chromosome Alignment Signal Transduction Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Wnt Signaling Pathway Vesicle-mediated Transport Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Nutrient Levels Positive Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Cell Division Protein Autoubiquitination Type I Interferon-mediated Signaling Pathway Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Regulation Of Primary Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Postsynapse RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Macroautophagy TBC/RABGAPs	Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RHOBTB3 ATPase cycle KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 25056061 28991256 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	72 interacting genes: ABTB1 ABTB2 AGFG1 ARHGEF12 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CEBPA CLK1 COMMD1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 FAM124B FOLR1 GABARAP GABARAPL1 GABARAPL2 GLUD1 GMCL1 GPS1 GYPA HLA-DMB HSF2 KCTD10 KCTD11 KCTD7 KLHL12 KLHL22 KLHL42 KLHL6 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NDUFA10 NEDD8 OLIG2 PDIA2 PDPK1 RBBP8 RBX1 RCBTB1 RHOBTB3 RIT1 RNF7 SHKBP1 SNX6 SRA1 SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 WNT7B ZAP70 ZMAT4
Entrez ID		11337	8452
HPRD ID		05496	09123
Ensembl ID		ENSG00000170296	ENSG00000036257
Uniprot IDs		O95166 Q6IAW1	B7Z600 Q13618
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A	2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8I79 8K8T 8K9I 8KHP 8U80 8U81 8U82 8U83 8U84
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Protein Modification By Small Protein Conjugation Protein Neddylation Post-translational Protein Modification Cellular Response To Nitrogen Starvation Protein Modification Process Cullin Family Protein Binding Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Phosphatidylethanolamine Binding Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Neddylation Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Mitophagy Protein K48-linked Ubiquitination Protein Tag Activity Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Starvation Ubiquitin-protein Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Autophagosome Maturation Protein Metabolic Process Protein Polyubiquitination Cytoplasm Autophagosome Assembly Autophagosome Membrane Response To Starvation Autophagosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Binding Ubiquitin Conjugating Enzyme Binding Macromolecule Catabolic Process Autophagosome Proteasomal Protein Catabolic Process Nucleus Mitotic Cell Cycle Phase Transition GABA Receptor Binding Cytosol Macroautophagy
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