RAD51C and PALB2

Number of citations of the paper that reports this interaction (PubMedID 24141787)
56

Data Source:
BioGRID (pull down)

		RAD51C	PALB2
Description		RAD51 paralog C	partner and localizer of BRCA2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Cell Junction Rad51B-Rad51C-Rad51D-XRCC2 Complex Rad51C-XRCC3 Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleoplasm Protein-containing Complex
	Molecular Function	Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Crossover Junction Endodeoxyribonuclease Activity	DNA Binding Protein Binding
	Biological Process	Meiotic DNA Recombinase Assembly Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Sister Chromatid Cohesion Female Meiosis Sister Chromatid Cohesion Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Factors involved in megakaryocyte development and platelet production	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Cognitive function ( 25644384) Primary tooth development (time to first tooth eruption) ( 23704328) Testicular germ cell tumor ( 23666239 23666240)	Bipolar disorder ( 17554300)
Interacting Genes		9 interacting genes: APP GATA3 PALB2 RAD51 RAD51B RAD51D SPG21 SWSAP1 XRCC3	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		5889	79728
HPRD ID		04143	07966
Ensembl ID		ENSG00000108384	ENSG00000083093
Uniprot IDs		O43502	H3BN63 Q86YC2
PDB IDs			2W18 3EU7
Enriched GO Terms of Interacting Partners?
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