PALB2 and DIRAS3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	DIRAS3
Description		partner and localizer of BRCA2	DIRAS family GTPase 3
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GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Plasma Membrane
	Molecular Function	DNA Binding Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression By Genetic Imprinting Small GTPase Mediated Signal Transduction
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	14 interacting genes: ACADM APC BAG4 BRMS1 CHEK2 FGFR4 HTR2A KRAS MEOX2 PALB2 PPM1D PTPN1 TGFB1 WT1
Entrez ID		79728	9077
HPRD ID		07966	05547
Ensembl ID		ENSG00000083093	ENSG00000162595
Uniprot IDs		H3BN63 Q86YC2	O95661
PDB IDs		2W18 3EU7	6NAZ
Enriched GO Terms of Interacting Partners?
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