PALB2 and PDS5B

Number of citations of the paper that reports this interaction (PubMedID 27924011)
21

Data Source:
BioGRID (pull down)

		PALB2	PDS5B
Description		partner and localizer of BRCA2	PDS5 cohesin associated factor B
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GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding Protein Binding	DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	DNA Repair Mitotic Sister Chromatid Cohesion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Division
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 27611488) Body mass index ( 25673413) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778 33020668) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (delayed recall) ( 29274321) Lung cancer ( 28604730) Mean platelet volume ( 27863252) Squamous cell lung carcinoma ( 28604730) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	5 interacting genes: APP BRCA2 HASPIN PALB2 RAD51
Entrez ID		79728	23047
HPRD ID		07966	05624
Ensembl ID		ENSG00000083093	ENSG00000083642
Uniprot IDs		H3BN63 Q86YC2	Q9NTI5
PDB IDs		2W18 3EU7	5HDT
Enriched GO Terms of Interacting Partners?
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