PALB2 and CASZ1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	CASZ1
Description		partner and localizer of BRCA2	castor zinc finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Regulation Of Transcription, DNA-templated Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Apolipoprotein B levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Beard thickness ( 26926045) Blood pressure ( 21572416) Blood urea nitrogen levels ( 31152163) Cataracts ( 34127677) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diastolic blood pressure ( 27841878 29403010 28739976 27618447 27618452 25249183 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology ( 31763980) Hypertension ( 25249183 30487518) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Male-pattern baldness ( 28196072) Mean arterial pressure ( 29403010 27618448 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Microalbuminuria ( 31511532) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Resistant hypertension ( 31545351) Stroke ( 29531354) Systolic blood pressure ( 19430479 27841878 29403010 28739976 27618452 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Urinary albumin-to-creatinine ratio ( 26631737 31511532) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	9 interacting genes: APP BAG4 BCAR3 ESR2 PALB2 PPM1D PTPN1 RAF1 WT1
Entrez ID		79728	54897
HPRD ID		07966	07897
Ensembl ID		ENSG00000083093	ENSG00000130940
Uniprot IDs		H3BN63 Q86YC2	B3KRV8 Q86V15
PDB IDs		2W18 3EU7
Enriched GO Terms of Interacting Partners?
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