PALB2 and LYPD3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	LYPD3
Description		partner and localizer of BRCA2	LY6/PLAUR domain containing 3
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GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane
	Molecular Function	DNA Binding Protein Binding	Laminin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Cell-matrix Adhesion
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Cotinine glucuronidation ( 25293881)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	18 interacting genes: AGR2 AGR3 ATP1A3 AURKA BAG4 BRMS1 CASP8 CHEK2 CTRB1 ERBB2 IGF1R LSP1 PALB2 PPM1D PTPRJ RB1CC1 SMAD4 STK11
Entrez ID		79728	27076
HPRD ID		07966	10783
Ensembl ID		ENSG00000083093	ENSG00000124466
Uniprot IDs		H3BN63 Q86YC2	B2RBR3 O95274
PDB IDs		2W18 3EU7	6IOM 6ION
Enriched GO Terms of Interacting Partners?
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