PALB2 and MRC2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	MRC2
Description		partner and localizer of BRCA2	mannose receptor C type 2
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GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Focal Adhesion Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Protein Binding	Protein Binding Collagen Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Osteoblast Differentiation Endocytosis Collagen Catabolic Process
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Blood protein levels ( 29875488) Diastolic blood pressure ( 28135244 30578418) Heel bone mineral density ( 30598549) Pulse pressure ( 28135244 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	14 interacting genes: AKT1 BAG4 BRMS1 ESR2 MTDH NDEL1 PALB2 PAX2 PPM1D PTPN1 RAF1 RB1CC1 SLC26A4-AS1 XRCC3
Entrez ID		79728	9902
HPRD ID		07966	10094
Ensembl ID		ENSG00000083093	ENSG00000011028
Uniprot IDs		H3BN63 Q86YC2	Q9UBG0
PDB IDs		2W18 3EU7	5AO5 5AO6 5E4K 5E4L 5EW6
Enriched GO Terms of Interacting Partners?
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