PALB2 and GREB1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	GREB1
Description		partner and localizer of BRCA2	growth regulating estrogen receptor binding 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Nucleoplasm Integral Component Of Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Multicellular Organism Development
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diisocyanate-induced asthma ( 25918132) Endometriosis ( 23104006 28537267) Gynecologic disease (multivariate analysis) ( 31488892) High density lipoprotein cholesterol levels ( 30108155) Inferior parietal cortex volume ( 31530798) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Uterine fibroids ( 30194396 31649266)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	11 interacting genes: BCAR3 CASP8 CDKN2C HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3
Entrez ID		79728	9687
HPRD ID		07966	13611
Ensembl ID		ENSG00000083093	ENSG00000196208
Uniprot IDs		H3BN63 Q86YC2	Q4ZG55
PDB IDs		2W18 3EU7
Enriched GO Terms of Interacting Partners?
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