ACO2 and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		ACO2	C5AR2
Description		aconitase 2	complement C5a receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Aconitate Hydratase Activity Iron Ion Binding Citrate Dehydratase Activity 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Liver Development Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Citrate Metabolic Process Isocitrate Metabolic Process Response To Isolation Stress	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis
Pathways		Mitochondrial protein import Citric acid cycle (TCA cycle)	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs		Isocitric Acid 4-Hydroxy-Aconitate Ion Alpha-Methylisocitric Acid Aconitate Ion Tricarballylic acid
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 32296059) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: APP ATXN1L C5AR2 CD244 CDC42 SUMO4	17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		50	27202
HPRD ID		00012	17072
Ensembl ID		ENSG00000100412	ENSG00000134830
Uniprot IDs		A0A7I2V586 Q99798	Q9P296
PDB IDs
Enriched GO Terms of Interacting Partners?
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