C5AR2 and SCN1B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		C5AR2	SCN1B
Description		complement C5a receptor 2	sodium voltage-gated channel beta subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Node Of Ranvier Perikaryon
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential
	Biological Process	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis	Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Sodium Ion Transmembrane Transport Locomotion Response To Pyrethroid Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Peptide ligand-binding receptors Regulation of Complement cascade	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Phenytoin Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases
GWAS			Metabolite levels ( 23823483) Serum albumin level ( 23022100)
Interacting Genes		17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234	6 interacting genes: ADRA1A ANK3 C5AR2 F2RL1 NFASC SCN2B
Entrez ID		27202	6324
HPRD ID		17072	02581
Ensembl ID		ENSG00000134830	ENSG00000105711
Uniprot IDs		Q9P296	A0A1W2PR05 Q07699
PDB IDs			6AGF 6J8G 6J8H 6J8I 6J8J
Enriched GO Terms of Interacting Partners?
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