C5AR2 and ACO2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		C5AR2	ACO2
Description		complement C5a receptor 2	aconitase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding	Aconitate Hydratase Activity Iron Ion Binding Citrate Dehydratase Activity 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis	Liver Development Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Citrate Metabolic Process Isocitrate Metabolic Process Response To Isolation Stress
Pathways		Peptide ligand-binding receptors Regulation of Complement cascade	Mitochondrial protein import Citric acid cycle (TCA cycle)
Drugs			Isocitric Acid 4-Hydroxy-Aconitate Ion Alpha-Methylisocitric Acid Aconitate Ion Tricarballylic acid
Diseases
GWAS			Adult body size ( 32376654) Asthma ( 32296059) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234	6 interacting genes: APP ATXN1L C5AR2 CD244 CDC42 SUMO4
Entrez ID		27202	50
HPRD ID		17072	00012
Ensembl ID		ENSG00000134830	ENSG00000100412
Uniprot IDs		Q9P296	A0A7I2V586 Q99798
PDB IDs
Enriched GO Terms of Interacting Partners?
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