EML4 and NEK7

Number of citations of the paper that reports this interaction (PubMedID 31409757)
5

Data Source:
BioGRID (enzymatic study)

		EML4	NEK7
Description		EMAP like 4	NIMA related kinase 7
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GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol Microtubule Membrane Midbody Mitotic Spindle	Spindle Pole Nucleoplasm Cytoplasm Microtubule Organizing Center Microtubule
	Molecular Function	Molecular_function Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Mitotic Metaphase Plate Congression Attachment Of Spindle Microtubules To Kinetochore Cell Division	Protein Phosphorylation Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Spindle Assembly Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Capping
Pathways		EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Metabolite levels ( 23823483) PR interval ( 32439900) Type 2 diabetes ( 31118516)	Age at first sexual intercourse ( 34211149) Height ( 28552196) High altitude adaptation ( 28373541) Pulse pressure ( 33230300)
Interacting Genes		7 interacting genes: ARIH2 ARL4D MTCH1 NEK6 NEK7 TUBA1B TUBB	8 interacting genes: C1orf53 EML4 LYN NEK9 PPP1R13B TERF1 TNNI1 ZBTB41
Entrez ID		27436	140609
HPRD ID		06310	06027
Ensembl ID		ENSG00000143924	ENSG00000151414
Uniprot IDs		B5MBZ0 Q9HC35	B2R8K8 Q8TDX7
PDB IDs		4CGC	2WQM 2WQN 5DE2 6NPY 6S73 6S75 6S76
Enriched GO Terms of Interacting Partners?
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