NEK7 and PPP1R13B

		NEK7	PPP1R13B
Description		NIMA related kinase 7	protein phosphatase 1 regulatory subunit 13B
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GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Microtubule Organizing Center Microtubule	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	P53 Binding Protein Binding
	Biological Process	Protein Phosphorylation Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Spindle Assembly Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Capping	Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neuron Death
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
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Diseases
GWAS		Age at first sexual intercourse ( 34211149) Height ( 28552196) High altitude adaptation ( 28373541) Pulse pressure ( 33230300)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 26426971) General risk tolerance (MTAG) ( 30643258) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglycerides ( 30275531)
Interacting Genes		8 interacting genes: C1orf53 EML4 LYN NEK9 PPP1R13B TERF1 TNNI1 ZBTB41	72 interacting genes: ACSF3 APC ARHGAP45 BFSP2 BRCA1 C2orf42 CAPN7 CBY2 CCDC102B CCDC184 CCHCR1 CDC5L CEP57 CEP63 CGN CKS1B DEUP1 DGCR6L DIRAS1 DTNB FAM184A FAM90A1 GAS2L2 GINS4 GOLGA1 HMG20B HNRNPUL1 KHDRBS1 KHDRBS3 KIF9 KIFC3 KRT20 KRT4 LMNB1 LMNB2 LMO1 LMO3 LNX1 MATN4 MCRS1 MIPOL1 MIS18A MLH1 NAP1L2 NDC80 NEK7 NHSL2 PLEKHA5 PPFIA3 PPP1CA PPP1R18 PRKAB2 PRPH PRR35 RALBP1 RASAL3 RASSF8 SALL1 SOGA1 TCL1A TEKT4 TEX12 TEX9 TNIK TP63 TP73 TRAF1 TSG101 TSGA10 TXLNA ZGPAT ZZZ3
Entrez ID		140609	23368
HPRD ID		06027	07345
Ensembl ID		ENSG00000151414	ENSG00000088808
Uniprot IDs		B2R8K8 Q8TDX7	Q96KQ4
PDB IDs		2WQM 2WQN 5DE2 6NPY 6S73 6S75 6S76	6HL5
Enriched GO Terms of Interacting Partners?
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