EML4 and ARIH2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EML4	ARIH2
Description		EMAP like 4	ariadne RBR E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol Microtubule Membrane Midbody Mitotic Spindle	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Molecular_function Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Mitotic Metaphase Plate Congression Attachment Of Spindle Microtubules To Kinetochore Cell Division	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Metabolite levels ( 23823483) PR interval ( 32439900) Type 2 diabetes ( 31118516)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: ARIH2 ARL4D MTCH1 NEK6 NEK7 TUBA1B TUBB	53 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R ITIH1 KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN REL RHEB RHOA RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		27436	10425
HPRD ID		06310	09286
Ensembl ID		ENSG00000143924	ENSG00000177479
Uniprot IDs		B5MBZ0 Q9HC35	O95376 Q53ET9 Q6IBL8
PDB IDs		4CGC
Enriched GO Terms of Interacting Partners?
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